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Illinois vs. Iowa State Prediction, Odds and Key Players for NCAA Tournament Sweet 16 (Trust Cyclones Defense)

Related Topics: Marcus Domask

The East Region semifinals pit the No. 1 offense in the country against the No. 1 defense in the country.

Following the first weekend of the 2024 NCAA Tournament, No. 2 seed Iowa State has become the best defense in the country and will look to slow down what is now the top offense in the nation in the eyes of advanced metrics website KenPom in Illinois.

Which style will win in this battle of titans?

Here’s our full betting preview.

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