The Southern Mississippi and South Alabama college football teams open the season against each other on Thursday, Sept. 3.
It marks the first college football game of the 2020 season between two Football Bowl Subdivision opponents.
South Alabama is coming off a 2019 season where it went 2-10 overall and 1-7 in the Sun Belt Conference.
USM finished 2019 at 7-6 overall and 5-3 in Conference USA. It capped last season with an appearance in the Armed Forces Bowl.
USM vs. South Alabama football betting odds
Southern Mississippi comes into the contest as a 14-point favorite against South Alabama, according to OddsShark.