Wolves' new £15million signing from Stuttgart, 6ft 7in Austrian striker Sasa Kalajdzic, could make his debut.
Southampton midfielder Romeo Lavia could be out for several weeks after suffering a muscle strain in midweek against Chelsea.
Ainsley Maitland-Niles and Duje Caleta-Car could come into contention after joining on deadline day.
MATCH FACTS
Head-to-head
- Wolves have won their last three Premier League games against Southampton, and four of the last five.
- Southampton have not won an away match at Wolves in their last six attempts - their last Molineux victory was a 6-0 triumph in the Championship in March 2007.