Conor Coady is set to make his 122nd consecutive league appearance for Wolves on Monday despite pulling out of England duty after a Covid-19 scare.
Rayan Ait-Nouri also withdrew from international duty and his adductor problem will be assessed, while Leander Dendoncker should be fit.
Southampton duo James Ward-Prowse and Ryan Bertrand are both available again after recent hamstring problems.
Saints' only absentee is Danny Ings, who has a knee injury.
LAWRO'S PREDICTION
Southampton showed they could cope without Danny Ings when they brushed Newcastle aside before the international break. This is a much sterner test, however.