West Ham are without a recognised left-back after Arthur Masuaku joined Aaron Cresswell on the sidelines with a knee injury.
Central defender Winston Reid will return, but Andre Ayew, Andy Carroll and Diafra Sakho remain out.
Southampton boss Claude Puel is expected to hand a start to Charlie Austin, who has scored four goals in his last three matches.
Fellow striker Jay Rodriguez is doubtful because of a knock.
MOTD COMMENTATOR'S NOTES
Guy Mowbray: "The form guide says Southampton to win, with three victories in a row suggesting they're on the right track after an initially sluggish start under Claude Puel.