Tottenham's interim head coach Ryan Mason takes charge of his first game on Wednesday following the sacking of Jose Mourinho on Monday morning.
Southampton forward Michael Obafemi isn't yet ready to make his comeback from leg surgery.
Injured pair Oriol Romeu and Will Smallbone are sidelined for the remainder of the season.
MATCH FACTS
Head-to-head
- Spurs could complete a league double against Southampton for the first time since 2017.
- Son Heung-min scored four goals in the reverse fixture when Tottenham won 5-2 at St Mary's.