Southampton forward Nathan Redmond has been ruled out with the ankle ligament injury he suffered in the League Cup match against Brentford.
Midfielder Stuart Armstrong could be available having missed their opening two matches with a thigh problem.
This is Tottenham's second of four matches in eight days so head coach Jose Mourinho is likely to make changes.
Defender Japhet Tanganga remains on the sidelines due to a thigh injury.
LAWRO'S PREDICTION
Gareth Bale is going to be an excellent signing for Tottenham, and he is the kind of player that will lift the whole dressing room when he walks through the door.