Adnan Januzaj is fit to play for Sunderland but John O'Shea and Jack Rodwell are nursing injuries and will be assessed.
Defender Papy Djilobodji will serve the third of a four-game suspension.
Southampton's club record signing Sofiane Boufal will miss Saturday's game at the Stadium of Light because of an ankle injury.
Nathan Redmond is pushing for a recall, having appeared as a substitute in last week's 3-1 home defeat by West Ham.
MOTD COMMENTATOR'S NOTES
Martin Fisher: "Last week's extraordinary and hugely unexpected 4-0 victory away to Crystal Palace breathed much-needed life into Sunderland's survival battle.