Southampton pair Kyle Walker-Peters and Stuart Armstrong are back in training after injuries but Saturday's game may come too soon for them.
Wolves will be without forward Hwang Hee-chan, who pulled his hamstring during the 3-0 win over Liverpool.
Mario Lemina hobbled off in that game but is fit to face his former club, while new signing Joao Gomes could make his debut.
CHRIS SUTTON'S PREDICTION
It appears that the majority of Southampton fans don't want Nathan Jones as the club's manager, which never bodes well.
To be honest, I thought that after some of the things Jones said after last weekend's humiliating defeat by Brentford he would be gone by the end of this week.