Loan signing Takumi Minamino is available for Southampton after being cup-tied for Thursday's win at Wolves.
Wolves will monitor Rayan Ait-Nouri and Jonny, who have both featured for the side this week and are being eased back into action after injury.
Fernando Marcal, Raul Jimenez, Willy Boly and Daniel Podence all remain on the sidelines.
Head coach Nuno Espirito Santo is likely to restore several players to the starting line-up after making six changes for the midweek FA Cup game, with Conor Coady, Pedro Neto and Willian Jose among those set to return.
LAWRO'S PREDICTION
Southampton keep on losing in the league, where they have now suffered five defeats in a row, but they did win at Wolves in the FA Cup on Thursday.