Southampton defender Jannik Vestergaard could be out for up to four weeks with a knee injury.
Oriol Romeu is available having missed Saints' Boxing Day draw with Fulham due to suspension.
West Ham may make changes after manager David Moyes admitted he got his team selection wrong against Brighton & Hove Albion on Sunday.
Forward Michail Antonio has returned to training following a hamstring problem.
LAWRO'S PREDICTION
Southampton were a bit subdued in their draw with Fulham, but they were missing some key men in Oriol Romeu, Jannik Vestergaard and Danny Ings.