Southampton manager Ralph Hasenhuttl could have Nathan Tella available if he returns a negative Covid test.
However, defenders Lyanco and Jack Stephens are still in self-isolation so miss out.
Tottenham defender Cristian Romero and midfielder Ryan Sessegnon remain on the sidelines due to injury, while Giovani Lo Celso is a doubt with a calf injury.
The likes of Dele Alli, Steven Bergwijn and Bryan Gil could be handed starts by head coach Antonio Conte.
MATCH FACTS
Head-to-head
- Since their return to the Premier League in 2012, Southampton have lost a club record 13 top-flight matches against Tottenham.