Ralph Hasenhuttl will use a mix of experience and youth for Southampton's third-round FA Cup tie with Shrewsbury Town on Tuesday.
"It will be a mixed group tomorrow," Hasenhuttl said. "Some young guys will have to step in."
The FA Cup tie was originally called off on 9 January after a coronavirus outbreak at the League One club.
A fourth-round home tie against Arsenal this Saturday at 12:15 GMT awaits the winner.
Southampton suffered defeat at Leicester in the Premier League on Saturday, with Hasenhuttl's squad feeling the strain of the fixture schedule and ongoing coronavirus restrictions.