Manchester United will assess the fitness of Raphael Varane, whose protracted move from Real Madrid was completed last weekend.
Jadon Sancho could start after making his debut as a substitute against Leeds United, while Edinson Cavani is in contention to return after he completed self-isolation protocols.
Southampton have no new injury concerns for the visit of Manchester United.
Sam McQueen and Will Smallbone are their only absentees.
LAWRO'S PREDICTION
I was there when United smashed Saints 9-0 at Old Trafford in February too. The scoreline won't be anything like that this time, but the points are heading for Manchester again - whether Paul Pogba plays as well as he did against Leeds last week or not.