Southampton striker Charlie Austin may make a first start since December following his return from injury.
Manager Claude Puel could again decide to freshen up his team after making seven changes against Middlesbrough.
Manchester United boss Jose Mourinho says that Daley Blind will definitely be rested after playing six out of their last seven matches.
Marouane Fellaini is available after a ban, but Paul Pogba is again unlikely to feature due to a family bereavement.
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RADIO 5 LIVE COMMENTATOR'S NOTES
Conor McNamara: "Bettering last season's top-six place was always going to be difficult for Southampton but this will be the first time in seven years that the club won't have improved their final league position.