Tino Livramento and Nathan Tella have been declared fit for Southampton as long-term injury victims Alex McCarthy and Lyanco remain their only absentees.
Tella has been out since January with a groin problem, while Livramento was rested for the league loss to Watford.
Manchester City are likely to remain without central defender Ruben Dias as he recovers from a hamstring strain.
Dias is back in training but unlikely to be risked while boss Pep Guardiola has no other fresh injury concerns.
City have reached at least the semi-finals in four of six seasons under Pep Guardiola, lifting the trophy once in 2019 when they claimed a historic domestic treble.