Southampton manager Ralph Hasenhuttl will be back in the dugout after a recent period of self-isolation.
Jannik Vestergaard and Nathan Redmond remain absent due to injury.
Liverpool defender Joel Matip is out for around three weeks with the groin injury sustained against West Brom on 27 December.
Thiago Alcantara could feature from the start, having impressed as a substitute on his return from injury against Newcastle on Wednesday.
LAWRO'S PREDICTION
I always feel like Southampton are better on the road, but their home form is decent too - the fifth best in the Premier League prior to the latest round of matches.