Virgil van Dijk and Ryan Bertrand are both likely to return for Southampton after sitting out the midweek FA Cup win over Norwich.
Jose Fonte will not be considered for selection while his future at the club remains uncertain.
Leicester's Leonardo Ulloa is struggling with a thigh injury and has also handed in a transfer request.
The Foxes are without Africa Cup of Nations trio Riyad Mahrez, Islam Slimani and Daniel Amartey.
MOTD COMMENTATOR'S NOTES
John Roder: "It was goalless when these two sides met earlier this season, and another 0-0 draw on Sunday has to be a strong possibility.