Southampton are boosted by the news that Oriol Romeu could return after nearly three months out with an ankle injury.
Leeds pair Mateusz Klich and Robin Koch will not play in their final two matches as they prepare for their potential involvement in Euro 2020.
Midfielder Pablo Hernandez faces a fitness test.
MATCH FACTS
Head-to-head
- Southampton have won five of their last six home league games against Leeds, including the last three in a row.