Defender Jan Bednarek is a doubt for Southampton, having been withdrawn at half-time in Tuesday's win over Crystal Palace because of an ankle injury.
Fulham - whose relegation was confirmed after defeat against Burnley on Monday - have no fresh injury concerns.
Tom Cairney is still out but fellow midfielder Harrison Reed has recovered from an ankle injury and could face his former club.
LAWRO'S PREDICTION
Southampton looked sharp against Liverpool last weekend and could easily have left Anfield with a draw, then Danny Ings came back to fire them to victory over Crystal Palace on Tuesday.