Che Adams is expected to play for Southampton despite struggling with a virus while on Scotland duty.
Ryan Fredericks might get a first start for the club after coming on for a substitute appearance against Wolves.
Everton full-back Nathan Patterson is out for at least four weeks with an ankle injury.
Goalkeeper Jordan Pickford is fit after a thigh issue and Dominic Calvert-Lewin could be involved following his recovery from a knee problem.
CHRIS SUTTON'S PREDICTION
I don't really know what to make of Southampton. They sometimes play with blood and thunder under Ralph Hasenhuttl, but other times they don't seem to attack very much at all.