Everton's James Rodriguez is hoping to shake off the knock he suffered in the Merseyside derby, but Jonjoe Kenny is not yet fit after an ankle problem.
Captain Seamus Coleman is sidelined with a minor injury and Richarlison begins a three-match ban.
Southampton's on-loan winger Theo Walcott is ineligible against his parent club, while Moussa Djenepo is still out with a hamstring injury.
Stuart Armstrong is set to return after a period of self-isolation.
LAWRO'S PREDICTION
Everton are still unbeaten but I have a feeling that run ends here.
Southampton are looking more like the side they were in the summer when they finished last season so strongly.