Southampton welcome back forward Che Adams, who missed the win against Leeds after suffering a minor muscle problem playing for Scotland.
James Ward-Prowse serves the second game of a three-match ban, while Jack Stephens is a long-term absentee.
Burnley will monitor the fitness of captain Ben Mee, who could come back into contention after missing their last fixture because of Covid-19.
The Clarets will also assess injury doubts Matej Vydra and Charlie Taylor.
LAWRO'S PREDICTION
Burnley are still waiting for their first league win of the season but Southampton got theirs against Leeds last week, which was big for them.