Southampton are hopeful that captain James Ward-Prowse will overcome a calf issue sustained on international duty with England.
The Saints are boosted by the news that both Danny Ings and Theo Walcott are back in training and available.
Burnley will be without Robbie Brady, who suffered an Achilles injury during Ireland's midweek game against Qatar.
Kevin Long and Ashley Barnes remain out, but Charlie Taylor and Jack Cork are both available again.
LAWRO'S PREDICTION
Both of these sides have got 33 points and, while they are not safe yet, I don't see either of them going down.