Southampton's Moussa Djenepo could feature despite being substituted against Manchester City on Wednesday because of a groin problem.
Brighton defender Tariq Lamptey is set to miss the rest of the season with a hamstring injury that could require surgery.
Aaron Connolly is also unavailable due to a cracked rib that will sideline him until after the international break.
LAWRO'S PREDICTION
For the first 15 minutes against Manchester City on Wednesday, Southampton played like they were the Pep Guardiola side. They were fabulous.
It didn't last though. Once you get past their high press, Saints seem to have a soft centre and they concede a lot of goals.