Southampton have Che Adams available again following a positive Covid test, with Mohammed Salisu back after a ban.
However, Thierry Small and Kyle Walker-Peters are still self-isolating, Yan Valery is suspended and Tino Livramento is injured.
Brentford could welcome back Sergi Canos and Mathias Jensen.
Josh Dasilva, Tariqe Fosu, Charlie Goode, Rico Henry, Mathias Jorgensen and David Raya remain out, while Frank Onyeka is at the Africa Cup of Nations.
MATCH FACTS
Head-to-head
- This is the first top-flight meeting between Southampton and Brentford.
- Brentford have earned successive 2-0 wins at St Mary's: in League One in December 2010 and the EFL Cup in September 2020.