Southampton manager Mauricio Pellegrino has described it as a 'blow' when his players are called up for international duty.
Saints full-back Ryan Bertrand was on Thursday named in England's squad for the upcoming friendlies against Germany and Brazil, while Three Lions manager Gareth Southgate opted to leave out Fraser Forster, James Ward-Prowse and Nathan Redmond.
Pellegrino could also lose a number of other key players for the forthcoming international break, including Northern Ireland midfielder Steven Davis, Dutch defenders Virgil van Dijk and Wesley Hoedt, Serbian winger Dusan Tadic, Republic of Ireland forward Shane Long and Italy striker Manolo Gabbiadini.