Joao Gomes rescued three points on the South Coast for Wolverhampton after scoring late to produce a comeback victory for the 10-men visitors.
Southampton remain cemented to the bottom of the Premier League table after a 1-2 draw against fellow relegation contenders Wolves in a hot-headed affair on Saturday as even more pressure is mounted on boss Nathan Jones.
Jones has now lost seven out of his last eight Premier League matches as Saints boss.
Southampton's January addition Carlos Alcaraz opened his Saint's goalscoring account in the 24th minute as he reacted quickest to an initial rebound off Wolves defender Craig Dawson and finish with a great strike that went in off the post.