Sunderland manager David Moyes believes progressing in the EFL Cup can help the Premier League's bottom club find form.
The Black Cats, who visit Southampton in the fourth round, have taken just two league points from the 27 available since Moyes took charge.
"I want to get through in the cup, I really do, but if possible I'd like to probably leave out John O'Shea, Jermain Defoe and Steven Pienaar," said Moyes.
Saints boss Claude Puel says record signing Sofiane Boufal will not start.
The midfielder, signed for £16m from Lille in the summer, is recovering from a knee injury and is likely to make his third substitute appearance of the season.