Inter Milan lost their 100% record this season as Simone Inzaghi's men were pegged back twice at Sampdoria.
Federico Dimarco's thunderbolt of a free kick put the visitors in front on 16 minutes before former Southampton centre back Maya Yoshida levelled for Roberto D'Aversa's side.
A scintillating dribble by Nicolo Barella was followed by an equally sumptuous cross from the Italian as Lautaro Martinez double his tally for the Nerazzurri this term after a summer of transfer speculation linking him to England.