Southampton will be without goalkeeper Aaron Ramsdale and centre-back Jan Bednarek for a number of weeks, says manager Russell Martin.
Ramsdale was among nine players to withdraw from England's squad last week because of a finger injury. Bednarek was forced off midway through Poland's 5-1 defeat by Portugal last Friday with concerns over a knee injury.
Bednarek is the only player to have started all 11 of Southamption's league matches this season.
Both players will miss Sunday's meeting with Premier League leaders Liverpool.
"They'll both be out for this weekend and a number of weeks," said Martin.