Southampton forwards Ross Stewart and Kamaldeen Sulemana have been ruled out through injury until January.
Deadline day signing Stewart picked up a muscle injury at Huddersfield on Saturday in just his second substitute appearance for Saints.
Sulemana injured his hamstring in Wednesday's win over Bristol City.
Boss Russell Martin told BBC Radio Solent: "Unfortunately they're both going to be out for quite a while. It's really disappointing - two big losses."
Scotland striker Stewart, 27, missed the start of the campaign with an Achilles injury after a reported £8m move from Sunderland and Martin said: "Ross is hugely disappointing because he's worked so hard to get fully fit.