Jay Rodriguez was among the Southampton players to see chances come and go in a narrow defeat at Inter, much to Claude Puel's frustration.
Southampton boss Claude Puel rued what could have been after a series of missed chances cost his side following a 1-0 Europa League defeat at the hands of 10-man Inter Milan.
The visitors dominated for long periods at San Siro, with Jay Rodriguez, Charlie Austin, James Ward-Prowse, Cuco Martina and Virgil van Dijk all going close to scoring.
Inter, in contrast, created very little, but Antonio Candreva's fine 67th-minute goal ultimately proved enough to condemn the Premier League side to their first defeat in Group K.