Southampton midfielder Oriol Romeu will miss the rest of the season with an ankle injury which will need surgery.
"He has a fracture on his ankle - it will take a minimum of three months until he is back" said Saints boss Ralph Hasenhuttl.
Southampton have several players out, including on-loan forward Takumi Minamino, who has a hamstring issue.
Defender Kyle Walker-Peters, midfielder Ibrahima Diallo and forward Theo Walcott will also miss Monday's Premier League match against Everton.