Midfielder Danilo will be assessed after limping off in Nottingham Forest's defeat by Brentford last week.
Brennan Johnson will also face a fitness test after coming off with a knock in that match.
Southampton defender Romain Perraud will miss the rest of the season after having ankle surgery.
Saints will also be without Mohammed Salisu, Juan Larios and Tino Livramento, but Paul Onuachu should be available after a minor knee problem.
CHRIS SUTTON'S PREDICTION
As I've said before, I've given up on Southampton.