Newcastle are depleted in defence, with Federico Fernandez and Jamaal Lascelles out, Jamal Lewis and Paul Dummett struggling and Ciaran Clark a doubt after his partner went into labour.
Southampton's Stuart Armstrong has been ruled out by a muscle problem but Jannik Vestergaard and Kyle Walker-Peters may be fit.
Jan Bednarek is available after his red card was rescinded.
New signing Takumi Minamino could make his debut but Alexandre Jankewitz, who was sent off in the midweek 9-0 defeat by Manchester United, is banned.
LAWRO'S PREDICTION
This is probably a good time to play Southampton, who are short of available players even though the red card Jan Bednarek received near the end of Tuesday's 9-0 defeat at Old Trafford was overturned.