Southampton suffered Premier League relegation after Aleksandar Mitrovic returned from his eight-match ban to help Fulham secure a 2-0 win at St Mary's.
Goals from Carlos Vinicius and Mitrovic inflicted a club-record 24th defeat of the season on the Saints to leave them eight points from safety with just two games left and a goal difference 20 goals worse than that of their nearest rivals.
The Saints have been through three managers this season, starting with Ralph Hasenhuttl before he was sacked, with Nathan Jones appointed.