Alex Telles returns for Manchester United after completing a period of isolation due to Covid-19 but fellow Brazilian Fred is still unavailable after testing positive for the virus.
Eric Bailly is out with a swollen ankle sustained at the Africa Cup of Nations.
Tino Livramento was rested by Southampton in midweek after his recent return from a knee problem but he is likely to play at Old Trafford.
Nathan Tella and Nathan Redmond will be assessed.
LAWRO'S PREDICTION
United are still very up and down during games and we saw again in their draw against Burnley that they don't seem able to play well for 90 minutes - they only seem to manage it for one half at the moment.