James Milner has been cleared to play for Liverpool after concussion and could make his 600th Premier League appearance.
Naby Keita may return from a thigh injury but Joel Matip is unlikely to be fit for Saturday's match.
Juan Larios will be assessed ahead of Southampton manager Nathan Jones' first game in charge of the club.
Fellow defenders Kyle Walker-Peters and Tino Livramento are long-term absentees.
CHRIS SUTTON'S PREDICTION
Nathan Jones takes charge of Southampton for the first time here but how much difference can he make in a couple of days? Saints just don't score enough goals but Anfield is not exactly the ideal place to go for a club to get a managerial bounce.