Liverpool manager Jurgen Klopp says he will assess the fitness of several unnamed players who are nursing minor injuries.
Southampton defender Jannik Vestergaard can play as his red card against Leicester has been overturned.
On-loan forward Takumi Minamino is ineligible to face his parent club, while Ryan Bertrand remains sidelined by a calf problem.
Danny Ings is not fit to face his former club but could return before the end of the season as he recovers from a hamstring problem.
LAWRO'S PREDICTION
I'm backing Liverpool to beat a Southampton team that is missing striker Danny Ings and does not have much to play for.