Leicester's Kasper Schmeichel played in the Champions League in midweek after injury and is set for his first league appearance since 10 September.
Defender Marcin Wasilewski is available after being banned for the defeat by Manchester United.
Southampton boss Claude Puel is likely to recall several players rested for the Europa League game in midweek.
Charlie Austin, Jose Fonte, Steven Davis and Ryan Bertrand are among those expected to be recalled.
MOTD COMMENTATOR'S NOTES
Steve Wilson: "Leicester seem to have taken to the Champions League as though to the manor born. Beating Brugge was commendable, beating Porto - a side of seasoned European campaigners - was excellent.