Leeds remain without six players because of injury, including key midfielder Kalvin Phillips.
Southampton boss Ralph Hasenhuttl says midfielder Stuart Armstrong has a "50-50" chance of recovering from a muscle problem in time to play on Tuesday.
Kyle Walker-Peters, Theo Walcott and Ibrahima Diallo are still sidelined.
MATCH FACTS
Head-to-head
- This is their first meeting in any competition since October 2012, when Leeds won 3-0 at home in a League Cup tie.
- Southampton are on a run of three straight league victories in this fixture, with the most recent being a 1-0 away win in March 2012.