Southampton would have taken a point before the match but having played against 10-men for much of the game, they will be disappointed to return from Stoke with only a 0-0 draw to show for their efforts.
Claude Puel's men failed to take full advantage of Stoke winger Marko Arnautovic's early red card as their profligacy in front of goal extended their poor record of only one Premier League away win this season.
Striker Shane Long was also lucky not to join Arnautovic in the dressing room after appearing to elbow defender Bruno Martins Indi.
Positives
Stoke is never an easy place to go so Puel will be pleased to pick up a second clean sheet in four days following Sunday's 1-0 win at home to Middlesbrough.