Saturday's FA Cup third round tie between Southampton and Shrewsbury is almost certain not to go ahead after a significant number of Shrews players and staff tested positive for coronavirus, BBC Shropshire reports.
Those affected at the Shropshire club are self-isolating.
All teams in the FA Cup are being tested 72 hours before their fixtures.
Shrewsbury's league game against Lincoln on 16 January is also said to be in doubt.
Southampton are sixth in the Premier League after beating leaders Liverpool on Monday.
Their cup meeting with Shrewsbury is the first between the two clubs since 2020-11, when Saints won their first-round tie 2-0.