There are two changes for Preston from their previous Championship game, a 2-1 win at Birmingham.
Ched Evans comes in up front to partner Tom Cannon, in place of Liam Delap who is cup-tied having played for Stoke City in round three.
Ben Whiteman for Ben Woodburn in midfield is the other change, the former Liverpool man is on the bench.
Preston XI: Woodman; Storey, Lindsay, Hughes; Browne, McCann, Ledson, Whiteman, Brady; Cannon, Evans
Subs: Cornell, Bauer, Diaby, Cunningham, Potts, Fernandez, Johnson, Woodburn, Cross-Adair
Antonio Conte makes seven changes to the Tottenham XI from the side which beat Fulham 1-0 in the Premier League on Monday.