Former Manchester United boss David Moyes takes his West Ham side to Old Trafford on Tuesday in one of the standout ties of the FA Cup fifth round.
Moyes, who spent 10 months as United manager in the 2013-14 season, has not won any of his five meetings with them since - but will things be different this time? You can find out by watching live on BBC One and the BBC Sport website from 19:00 GMT.
BBC football expert Mark Lawrenson has given his verdict on all eight midweek ties and he is joined in making predictions by Jack Saunders, who presents Radio 1's Future Artists every Monday to Wednesday from 22:00 to 00:00 GMT, and The Indie Show at the same time on Thursdays.