Alex Iwobi, a Premier League ever-present for Everton this season, will miss around three weeks due to the ankle injury sustained during the FA Cup loss at Manchester United.
Southampton expect Carlos Alcaraz to be available following his £12m move from Racing Club in Argentina.
Alex McCarthy and Theo Walcott could return but Armel Bella-Kotchap is among four players definitely out.
CHRIS SUTTON'S PREDICTION
The last week has shown the importance of the cup competitions in changing the mood at a club - just ask Southampton boss Nathan Jones.
Jones had lost his first four Premier League games with Saints but beating two top-flight teams, Crystal Palace and Manchester City, in the FA Cup and Carabao Cup will really get the fans on his side.