Everton pair Dominic Calvert-Lewin and Allan are both in contention to start, having been named as substitutes for the Merseyside derby last time out on their return from injury.
Southampton midfielder Oriol Romeu has been ruled out for the remainder of the season with a fractured ankle sustained against Leeds.
Takumi Minamino is out with a hamstring strain but could be fit within a week.
They join Kyle Walker-Peters, Theo Walcott, Ibrahima Diallo, Will Smallbone and Michael Obafemi on the sidelines.
LAWRO'S PREDICTION
Southampton are in a slump and this is a tough trip for them, even if Danny Ings does return to their team.