Chelsea midfielder N'Golo Kante continues to self-isolate following a positive Covid-19 test, while Christian Pulisic is expected to again miss out through injury.
Mason Mount and Reece James are nursing minor problems and will be monitored.
Southampton will assess Stuart Armstrong, who has resumed training following a calf injury, while Theo Walcott is fit after a similar issue.
Loanee Armando Broja is ineligible to face his parent club.
LAWRO'S PREDICTION
Chelsea have lost their past two games, against Manchester City and Juventus, but this is not the start of any serious slump.
Blues boss Thomas Tuchel will demand a performance this time, and I would be shocked if their losing run continues on Saturday.