Burnley's Scott Arfield and Johann Berg Gudmundsson are unlikely to play because of hamstring injuries suffered in the FA Cup last weekend.
But George Boyd and Jon Flanagan are set to return after minor problems, with Ashley Barnes also fit again.
Southampton's Steven Davis faces a fitness test after coming off with a knock against Liverpool in midweek.
Saints have no other injury worries but Jose Fonte is still absent after making a transfer request.
MOTD COMMENTATOR'S NOTES
Steve Wilson: "Only Spurs and Chelsea have won more Premier League home games this season than Burnley, which should be both a source of pride to everyone at Turf Moor and a reason to fret for Southampton.